HDI may refer to:

• Human Development Index, a United Nations measure of well-being in a country
• Help Desk Institute, a trade association
• PSA HDi engine, a diesel automobile engine by Peugeot/Citroën
• Hexamethylene diisocyanate, an organic compound used to make polymers such as polyurethane
• HDi Interactive Format (formerly iHD), a trademark for Microsoft's implementation of advanced interactivity for HD DVD
• Histone deacetylase inhibitor, compounds used in psychiatry and neurology, and with anticancer potential

See also:

• HDI-45 connector, a video connector by Apple Inc.

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