Cocaine has several meanings

• Cocaine, an alkaloid derived from the coca plant.
• Cocaine (drink), an highly caffeinated energy drink that does not contain the alkaloid cocaine
• "Cocaine" (song), a blues song by J.J. Cale, later covered by Eric Clapton
• "Cocaine" (song), a song written by rev. Gary Davis, Jackson Browne & Glenn Frey in 1968.
• "Cocaine", a poem by Patti Smith from her 1972 book Seventh Heaven

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